A whopping five backup quarterbacks must be deployed in Week 3 in the NFL due to injury, which may be a record this early in a season. Jay and Dre hand out their awards for Week 2 before deciding how to pick the games in Week 3 that have all these replacement QBs, as well as the regular ones. Who's on the side of backup Mac Jones and the 49ers versus Kyler Murray and the Cardinals as the boys engage in a Lock-Off? The answer may surprise you. They also preview a physical battle between the 2-0 Rams and Eagles, a pivotal divisional matchup between the Broncos and Chargers, and a Monday night war that may be high-scoring featuring Jay's Super Big Game prediction, the Lions and Ravens.