Hosts Brad Fowler and Alex Higdon preview 4 of the biggest NFL games and 3 top-25 College Football matchups this weekend — and give their betting picks for each one.

We cover — whether the Seahawks can hang with the Jaguars in Florida, if the Bucs can keep it going against the 49ers, and whether the Lions are set for a letdown vs. the Chiefs. Will the Bears pull the upset over the Commanders on Monday Night Football. Plus, we break down Oregon vs. Indiana and whether Missouri can pull off a shocker against Alabama, and if Ohio State will dominate Illinois. Stick around until the end for a couple of quick bonus picks to close out the episode.

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