Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics Anthony R. Gregg, MD, MBA, Brian G. Skotko, MD, MPP, Judith L. Benkendorf, MS, Kristin G. Monaghan, PhD, Komal Bajaj, MD, Robert G. Best, PhD, Susan Klugman, MD and Michael S. Watson, MS, PhD Gregg, AR et al. Noninvasive prenatal screening for fetal aneuploidy: 2016 update Abstract Noninvasive prenatal screening using cell-free DNA (NIPS) has been rapidly integrated into prenatal care since the initial American College of Medical Genetics and Genomics (ACMG) statement in 2013. New evidence strongly suggests that NIPS can replace conventional screening for Patau, Edwards, and Down syndromes across the maternal age spectrum, for a continuum of gestational age beginning at 9–10 weeks, and for patients who are not significantly obese. This statement sets forth a new framework for NIPS that is supported by information from validation and clinical utility studies. Pretest counseling for NIPS remains crucial; however, it needs to go beyond discussions of Patau, Edwards, and Down syndromes. The use of NIPS to include sex chromosome aneuploidy screening and screening for selected copy-number variants (CNVs) is becoming commonplace because there are no other screening options ...