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Immunologists at the Medical University of South Carolina have found a way to direct the body’s immune system to censor itself permitting transplanted human organs to flourish with medicinal immunosuppression.  Their study appeared recently in Frontiers in Immunology.

The investigators genetically engineered so-called regulatory T cells, Treg lymphocytes, to selectively destroy those B lymphocytes programmed to produce the antibodies that attack transplanted organs. This self-immunosuppression could extend the life of transplanted organs and permit so-called presensitized patients with pre-existing B lymphocytes ready to churn out anti-organ antibodies an opportunity for successful transplantation. 

Let’s hope clinical trials demonstrate the utility of this approach.

https://www.news-medical.net/news/20250817/Genetically-engineered-immune-cells-show-promise-for-preventing-organ-rejection.aspx

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1601385/full

#transplantation #immunosuppression #Treg #antibodies #presensitized