Jesse Sapolu is a former football player in the National Football League. Sapolu played both center and offensive guard, and spent his entire career in a San Francisco 49ers uniform.

Sapolu is one of six 49ers to own four Super Bowl championship rings (1984, 1988, 1989, and 1994), and the only one of those to earn a ring with the '94 team rather than their first title in 1981. He earned Pro Bowl honors in 1993 and 1994.

Since retiring in 1997, Sapolu lives in Costa Mesa, California, and remains active in the community as well with the San Francisco 49ers alumni. He is also an offensive line coach for the Brethren Christian Junior/Senior High School Warriors and Edison High School Chargers in Huntington Beach, California.

Jesse has been an integral part in establishing the Polynesian Pro Football Hall of Fame, and is one of the board members.