Jesus faced opposition from his own family who thought he had lost his mind during his ministry. When his mother and brothers came to take him away, Jesus used this moment to teach about true family relationships. He declared that anyone who does God's will becomes his brother, sister, and mother. This passage reveals the difference between passive observation and active discipleship - those standing outside versus those sitting at Jesus' feet learning from him. As believers, we belong to a global family united by Christ's blood, which sometimes means our obedience to God's calling takes precedence over family expectations.