Editor-in-chief Shawn Kennedy and Clinical Editor Betsy Todd present the highlights of the October issue of the American Journal of Nursing. The political cartoon on this month’s cover, created by two-time Pulitzer Prize-winning editorial cartoonist David Horsey, is a commentary on the contentious circumstances leading up to the 2016 presidential election. Our first CE, “An Overview of Common Oral Treatments for Breast Cancer: Improving Patient Safety in Nononcology Settings,” reviews the most common oral agents used to treat breast cancer and their possible adverse effects and interactions. In our second CE, “Assessing and Managing Pain, Agitation, and Delirium in Hospitalized Older Adults,” the authors provide an overview of clinical considerations related to the assessment and treatment of pain, agitation, and delirium. Our next article, “Perspectives on Palliative Nursing: For Advanced Cancer, What Treatment Is Next?” discusses how nurses can best serve patients faced with the choice between aggressive treatments and palliative or hospice care. In “Ethical Issues: Determining When an Activity Is or Is Not Research,” the authors examine the ethical and practical significance of making a distinction between research and not research when using data to identify best practices and improve care. In addition, there’s News, Reflections, Drug Watch, Art of Nursing, and more.