Eyes On Tomorrow

Oculomics and the AI Revolution, with Prof. Pearse Keane


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In 1964, Captain James T. Kirk set the tone for a generation when he declared: “Space—the final frontier….to explore strange new worlds…. to boldly go where no man has gone before.” Today, that spirit of exploration has found a new frontier — not in space, but in the human eye.

In this episode of Eyes on Tomorrow, we’re joined by Professor Pearse Keane, Professor of Artificial Medical Intelligence at UCL. Like a modern-day Captain Kirk, Pearse is leading ophthalmology on a voyage of discovery, using AI to take us to truly “strange new worlds” — and revealing what the retina can tell us about our risk of systemic disease.

Pearse explains why ophthalmology is uniquely placed to ride the AI wave, and how a speculative LinkedIn message sparked a collaboration with Mustafa Suleyman that led to the groundbreaking partnership between Moorfields Eye Hospital and Google DeepMind.

We explore the rise of oculomics, from predicting age and sex using a single colour fundus photograph, to using large language models and retinal imaging to stratify risk for cardiovascular and neurological disease. We also tackle the ethical challenges this technology raises, including data protection, and look ahead to how AI will bring optometrists, primary care doctors, and hospital specialists closer together than ever before.

It may sound like science fiction, but this is science fact. This conversation offers a glimpse into a “brave new world” that’s closer than we think.

Bonus subscriber content

In this month’s bonus episode Pearse discusses RETFound, the first foundation model in medicine, capable of predicting myocardial infarction, heart failure, and ischaemic stroke from unlabelled retinal images. Pearse tells us how, by making this AI open-source, it is democratising access to this transformative technology.

Get access to this Bonus episode, along with a host of CPD resources, when you subscribe for only £25 per year at [email protected]/subscribe.

Eyes on Tomorrow is supported by Topcon Healthcare and Thea UK.

Produced by Matt Hill at Rethink Audio.



This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit eyesontomorrow.substack.com/subscribe
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