In part 2 of our discussion on Alzheimer's diagnostics, our host, Jane Caldwell, speaks with Dr. Francesca De Simone. Dr. De Simone is Scientific Affairs Manager for Fujirebio Diagnostics and leads the company's neurodegenerative disease program. Dr. De Simone discusses the role of blood-based biomarkers for Alzheimer's disease in comparison to other forms of diagnostic tests, as well as her insights on the clinical needs for Alzheimer's and current progress in the field. 

Educational support provided by Fujirebio Diagnostics.

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Join our host Jane Caldwell for a discussion with Dr. Douglas Galasko, the Associate Director of the UC San Diego Shiley Marcos Alzheimer's Disease Research Center. Dr. Galasko will discuss the recently approved pTau217/β-Amyloid 1-42 plasma ratio test, the first blood biomarker test for Alzheimer's disease. He will talk about the role of this and other diagnostic tools, and what an early diagnosis can mean for patients and their families.

Educational support provided by Fujirebio Diagnostics.

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Join our host Jane Caldwell for a conversation with pharmacists Duane Jones and Jennifer Griffin on how a pharmacy test-and-treat program can improve access to care. Duane and Jennifer share their best practice case of implementing a testing and billing workflow at the Harps Pharmacy network that improved patient care and provided needed reimbursement for pharmacy sustainability. They discuss details of their implementation and how other pharmacies can do the same. OMG has worked with Duane and Jennifer to provide resources for pharmacies who may be interested in starting their own test-and-treat programs to fill care gaps and improve sustainability.

For resources on implementing pharmacy-based test-and-treat programs, please visit:
https://cpesn.com/
https://naspa.us/
https://www.pharmacist.com/

Educational support provided by QuidelOrtho.

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Andre Bennett, 59-year-old photographer recently returned from Africa, shows up to his doctor with a rash, fatigue, sore throat, and headache. The location of the rash makes this case seem cut and dry... but is it? Halfway through, his doctor starts to change course. Would you?

This Medical Mystery Case is accredited for 0.5 hours of FREE continuing education credit for physicians, nurses, and laboratory professionals. By the time participants have completed listening to the podcast and viewing the accompanying materials at OnMedicalGrounds.com, they will be able to address the following Learning Objectives:

Learning Objectives

• Assess real-life challenges with HSV/VZV diagnosis.
• Integrate information on lesion analysis and improved diagnostic techniques.
• Identify and describe benefits of multiplex testing to improve outcomes.

To receive credit for this program, please visit the link below, review the slides and links, and click CME/CE to fill out an evaluation and get your certificate.

The Over Exposure

This continuing medical education program was supported by QuidelOrtho.

This podcast was planned and developed by Medavera for release on the On Medical Grounds podcast. 

Voice actors
Narrator: Jane Caldwell, PhD
Plane Captain: Jack Murphy
Andre Bennett:  Kyle Stewart
Nurse Sam:  Jesse Adam
Dr. Chandra Johnson: Indasa Butler

No voice actors, planners, or developers have disclosures to declare or mitigate for this educational program.

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Today is part three of Polio Confidential: Stories from Those Who Lived It, How A Virus Changed History. Today we are speaking with Dr. William Schaffner.

Dr. Schaffner is a Professor of Preventive Medicine and Infectious Diseases at the Vanderbilt University School of Medicine. Early in his career, he was commissioned as an Epidemic Intelligence Service Officer with the CDC in Atlanta, where he investigated outbreaks of communicable diseases in the U.S. and internationally. Dr. Schaffner has worked extensively for the effective use of vaccines in both pediatric and adult populations and has been a member of numerous expert advisory committees that establish national vaccine policy and is committed to public communication about medicine. 

(00:18) Introduction
(02:37) Was polio still an issue in 1962?
(03:16) Dr. Schaffner was a Polio Pioneer
(05:44) Memorable encounter with a polio patient
(08:03) Growing up with those affected by polio
(09:16) Signs and symptoms of polio virus infection
(11:05) Description of an iron lung
(15:34) Story about training doctors on use of an iron lung
(18:40) Should non-medical vaccine exemptions be allowed?
(20:16) How should we talk to parents about polio and vaccines?
(21:47) What keeps Dr. Schaffner up at night?

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Today is part two of Polio Confidential: Stories from Those Who Lived It, My Journey After Contracting Polio. Today we are speaking with Janice Nichols. In 1954, she was one of over 1.8 million children who participated in the Salk polio vaccine trial, dubbed the “polio pioneers.” Their study led to the successful production of the first polio vaccination. Prior to this study, Jan was diagnosed with polio as was her twin brother, Frankie. Her brother was lost to the disease while Jan survived.

(00:25) Introduction
(02:17) Jan and Frankie's story
(07:56) How was polio viewed by families?
(10:53) How was the Salk trial conducted?
(13:38) Jan describes her post-polio syndrome.
(16:30) What would Jan share with Frankie today?

Jan is the author of “Twin Voices, A Memoir of Polio, The Forgotten Killer.”  You can also read a summery of her story her story and more than 100 personal accounts and case reports about vaccine preventable diseases at Immunize.org.

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Today is part one of Polio Confidential: Stories from Those Who Lived It, The Continued Path Toward Prevention. Today we are speaking with Dr. Paul Offit about the history of polio, the polio vaccine, and the rise of the modern anti-vaccine movement. 

Dr. Offit is a professor of pediatrics and attending physician at the Division of Infectious Diseases at the Children's Hospital of Philadelphia. As director of the Vaccine Education Center at that institution, he is an internationally recognized expert in the fields of virology and immunology. Dr. Offit is a member of the FDA Vaccine Advisory Committee. 

(00:17) Introduction
(01:54) Dr. Offit's friendship with Maurice Hilleman
(03:28) Why write?
(04:35) How does FDA and CDC decide a vaccine isn't safe?
(05:45) A bit of polio history and Dr. Offit's memories of growing up before the polio vaccine
(07:19) How as U.S. society different from today with regards to vaccines?
(08:55) The Cutter Incident
(10:32) How would the Cutter Incident be different now?
(11:12) What was the birth of the modern anti-vaccine movement?
(13:06) What motivates anti-vaxxers?
(14:23) What is the current status of polio?
(17:01) Is polio dangerous today?
(17:50) Have we forgotten polio?
(18:40) Should we be afraid of the incoming administration?
(19:45) How much can a political administration control vaccine approval and recommendations?
(20:52) If you have already had the polio vaccine, do you need a booster?
(21:11) What does Dr. Offit recommend telling a parent or patient who is vaccine-hesitant?
(22:05) What could we have done differently with COVID and COVID vaccines?
(25:00) What should we do now to promote vaccines and vaccine safety?
(25:35) What is Dr. Offit up to next?

For more from Dr. Offit, please see his website: https://www.paul-offit.com/
Books: https://www.paul-offit.com/recent-books
Shot in the Arm documentary: https://www.paul-offit.com/general-9
Newsletter: https://pauloffit.substack.com/

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Today we are going to give you the scoop on whooping cough, also known by the less friendly name, pertussis, the infection caused by the crafty and toxin-producing bacteria Bordetella pertussis. 

According to data from the CDC, rates of whooping cough are currently 3X higher than in 2023 and still climbing. Why? Listen and find out.

Visit us at OnMedicalGrounds.com for more podcasts or download our app! You can subscribe through your podcast platform, our website, or follow us on social media for podcast updates and medical news. Some of our podcasts offer FREE CME/CE credits.
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Today On Medical Grounds, we will be speaking with Dr. Matt Binnicker, Director of Clinical Virology at Mayo Clinic about bird flu. Highly pathogenic avian influenza viruses have been detected in wild aquatic birds, commercial poultry, and backyard flocks beginning around January 2022 in the U.S. To date, over 100,700,000 birds have been affected. Recently, cases of bird flu have been detected in 171 dairy herds, and there have been 13 reported human cases in the U.S. There have also been human cases reported overseas. Dr. Binnicker joins us to share his knowledge of bird flu, vaccines, and whether we need to be concerned about a new pandemic.

(00:09) Introduction to Dr. Binnicker
(01:12) Introduction to bird flu
(03:57) Morphology and rapid mutation of avian influenza
(06:47) The problem with pigs
(09:23) Human concerns
(11:11) Transmission through raw milk
(13:33) Developing a lab test for H5 avian influenza
(17:15) H5 vaccinations and vaccine availability
(20:33) Role of climate change in a future avian influenza pandemic
(22:27) What keeps Dr. Binnicker up at night

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Today On Medical Grounds, we will be speaking with Dr. Jon Temte about the alarming rise in measles infections in the United States. Dr. Temte is Professor of Family Medicine at the University of Wisconsin School of Medicine and Public Health. Back in 2000, he was part of an expert panel that concluded that measles were eliminated in the United States. That same expert panel recertified measles elimination in 2011. Dr. Temte also chaired the advisory committee on immunization practices, which issued a report in 2013 for the prevention of measles, rubella, congenital rubella syndrome, and
mumps.

We will discuss the current measles outbreak in the U.S., the scarcity of healthcare providers that have actually seen a case of measles, short and long-term complications, and some interesting information about the measles vaccine. Dr. Temte also shares his personal worries as someone who has seen both the elimination of measles and its rampant spread.

(00:12) Introduction
(01:16) CDC measles emergency warning
(02:35) Measles symptoms
(06:42) Short and long-term effects
(08:27) Children and adult vaccination status
(09:49) U.S. measles elimination status
(10:42) Eradication vs. elimination
(14:38) Herd immunity
(17:17) False sense of security
(18:23) Vaccine hesitancy and autism
(19:48) How to address vaccine hesitant patients
(21:21) Older adults needing boosters
(24:19) Dr. Temte's worries and closing thoughts

Visit us at OnMedicalGrounds.com for more podcasts or download our app! You can subscribe through your podcast platform, our website, or follow us on social media for podcast updates and medical news. Some of our podcasts offer FREE CME/CE credits.
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