In this episode, Dr. Brian Garibaldi, Charles Horace Mayo Professor of Medicine and Director of the Center for Bedside Medicine at the Northwestern Feinberg School of Medicine, shares his journey from basic science research to becoming a leading voice in clinical education and bedside medicine. We discuss his transformative experience helping establish a medical school in Malaysia and his leadership role at the Johns Hopkins Special Pathogens Center during the COVID-19 pandemic. Dr. Garibaldi reflects on the irreplaceable value of bedside skills, the human connection that sustains both patients and physicians, the impact of mentorship on shaping a meaningful career in medicine, and the courage to embrace uncertainty along the way.