With Brain-centric Design, the new 3Rs—Reflect, Revised Thinking, and Report Out—define processes and practices that change that original and outdated paradigm. Paradoxical and delightful outcomes emerge. Even though the focus is not on reading, writing, or arithmetic, these same proficiencies improve, along with a learner’s capacity to grow intellectually, socially, and emotionally. The simple measure of connecting neuroscience with teaching and learning invokes a paradigm shift in attitude, mental models, and intention for both the teacher and the learner.