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Once An Addict, Always An Addict, But Is It True For The Brain? Dopamine in Drug Craving, Wanting vs Liking || NeuroDrugs Clip
#addiction #neuroscience #memory #wanting #liking #addictedbrain
From NeuroDrugs #2 - streamed live July 15, 2020.
Full conversation: https://youtu.be/X8_fSqM7AZI
How long does it take for the addicted brain to go back to normal, or when brain dopamine receptor levels take to return to baseline following addiction? As the saying goes, once an addict, always an addict, but is this true for the brain?
We're a group of Canadian neuroscientists reviewing the latest news, events and scholarly publications from this week in neuroscience and beyond! In each NeuroDrugs live stream we review classics in the field of addiction neuroscience, as well as newly published articles on a weekly basis.
In this clip we comment on the breakthrough neuroscience research article that began the 'wanting/liking' dichotomy that researchers are still investigating to this day. Titled "The neural basis of drug craving: An incentive-sensitization theory of addiction", Terry E. Robinson & Kent C. Berridge present a bio - psychological theory of drug addiction, the ‘Incentive-Sensitization Theory’.
The theory addresses three fundamental questions.
1) why do addicts crave drugs?
2) why does drug craving persist even after long periods of abstinence?
3) Whether 'wanting' drugs (drug craving) is attributable to ‘liking’ drugs (to the subjective pleasurable effects of drugs)? Or possibly due to external components altogether.
The incentive-sensitization theory of addiction posits the following.
1. Addictive drugs enhance dopamine transmission in brain reward regions
2. A major psychological function of this neural system is to attribute ‘incentive salience’ to the perception and mental representation of events associated with activation of the system (drug associated cues and stimuli).
3. In some individuals the repeated use of addictive drugs produces adaptations in this system, rendering it increasingly and perhaps permanently, hypersensitive (‘sensitized’) to drugs and drug-associated stimuli. This is ultimately a learning & memory based effect.
open access articles: https://www.sciencedirect.com/science/article/abs/pii/016501739390013P
& https://www.sciencedirect.com/science/article/pii/S2352154617301948)
Join us for NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube for the largest interactive live streaming journal club & contribute to the conversation! Stay tuned to stay up to date with the latest in neuroscience / general science news!
A Production of First-Person Science
Please subscribe @ www.youtube.com/firstpersonsciencepodcast if you enjoy our content, and share it with friend and platforms that might be interested! It goes a long way in helping us stamp out misinformation in neuroscience media!
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#addiction #neuroscience #memory #wanting #liking #addictedbrain
From NeuroDrugs #2 - streamed live July 15, 2020.
Full conversation: https://youtu.be/X8_fSqM7AZI
How long does it take for the addicted brain to go back to normal, or when brain dopamine receptor levels take to return to baseline following addiction? As the saying goes, once an addict, always an addict, but is this true for the brain?
We're a group of Canadian neuroscientists reviewing the latest news, events and scholarly publications from this week in neuroscience and beyond! In each NeuroDrugs live stream we review classics in the field of addiction neuroscience, as well as newly published articles on a weekly basis.
In this clip we comment on the breakthrough neuroscience research article that began the 'wanting/liking' dichotomy that researchers are still investigating to this day. Titled "The neural basis of drug craving: An incentive-sensitization theory of addiction", Terry E. Robinson & Kent C. Berridge present a bio - psychological theory of drug addiction, the ‘Incentive-Sensitization Theory’.
The theory addresses three fundamental questions.
1) why do addicts crave drugs?
2) why does drug craving persist even after long periods of abstinence?
3) Whether 'wanting' drugs (drug craving) is attributable to ‘liking’ drugs (to the subjective pleasurable effects of drugs)? Or possibly due to external components altogether.
The incentive-sensitization theory of addiction posits the following.
1. Addictive drugs enhance dopamine transmission in brain reward regions
2. A major psychological function of this neural system is to attribute ‘incentive salience’ to the perception and mental representation of events associated with activation of the system (drug associated cues and stimuli).
3. In some individuals the repeated use of addictive drugs produces adaptations in this system, rendering it increasingly and perhaps permanently, hypersensitive (‘sensitized’) to drugs and drug-associated stimuli. This is ultimately a learning & memory based effect.
open access articles: https://www.sciencedirect.com/science/article/abs/pii/016501739390013P
& https://www.sciencedirect.com/science/article/pii/S2352154617301948)
Join us for NeuroBeer every Monday (8pm EDT) & NeuroDrugs every Wednesday (9pm EDT) on YouTube for the largest interactive live streaming journal club & contribute to the conversation! Stay tuned to stay up to date with the latest in neuroscience / general science news!
A Production of First-Person Science
Please subscribe @ www.youtube.com/firstpersonsciencepodcast if you enjoy our content, and share it with friend and platforms that might be interested! It goes a long way in helping us stamp out misinformation in neuroscience media!