How have cultural and historical shifts over the 133-year lifetime of Osteopathy changed the clinical practice of our profession? We all recognize that the Osteopathic practice has evolved since 1892—but our patients have changed as well. Robert Fulford, DO once said, “Patients were a lot easier to treat before World War II.” We will explore how more recent cultural events and social upheavals have changed the patient population and therefore, have changed the way we practice clinical Osteopathy.