This review podcast episode examines the efficacy and safety of oxandrolone, an anabolic androgenic steroid (AAS), in treating various wasting and catabolic disorders. It explores the drug's pharmacokinetic and pharmacodynamic properties, noting its unique resistance to liver metabolism compared to other oral AASs. The text details oxandrolone's clinical benefits in conditions like severe burns, HIV/AIDS-related wasting, and neuromuscular disorders, highlighting improvements in body composition and muscle function. Furthermore, the article addresses the potential for adverse effects, particularly concerning hepatic issues and cholesterol changes, while also discussing the drug's potential utility in treating age-related sarcopenia. Ultimately, it concludes by advocating for more extensive, long-term research to optimize its therapeutic application.