This week on the On Your Mind Neuroscience Podcast:   Kat's away, and Liam is reunited with Adel Farah. Long time listeners will remember that a year ago Adel left academia for medschool, and Liam has recently decided that he will be leaving academia for.... something. We have a long chat about our motivations for leaving and what we have found, or hope to find, in the next phases of our careers.    This week Liam is bummed that he doesn't live in the States, because it means he can't sign up for Genes for Good, an academic project that periodically collects health data from you, then sends you a DNA kit and correlates genetic findings with health outcomes. If you ask them they'll also send you the results of your gene profiling, but you'll have to go elsewhere for interpretation.    Adel has been thinking about something similar, but for tumors. A recent commentary in Nature proposed a banking of genetic samples from all tumors, alongside long term patient outcome information. This could help up get a lot more insight into the genetics or cancers that go into remission, or have a high chance of resurfacing.    Finally, our paper this week (OA) deals with the interaction of pain signaling and pain relief signaling by showing that activation of a "pain receptor" (NK1R) can increase the signaling of a pain relief signaling through the mu opioid receptor (MOR) by increasing its recycling to the cell membrane.    NKR signals through Protein Kinase C, and a PKC inhibitor removed the ability of NK1R to incrase MOR recycling while activating PKC independant of NK1R increased recycling. PKC seems to act by phosphorylating sites directly on MOR.    Finally they showed that giving mice Substance P, a terrifyingly named activator of NK1R, helped the opioid Fentanyl maintain it's effectiveness over two doses.    For links to everything we talked about today, full shownotes, and past episodes head to www.onyourmind.ca