The Panama Disappearance Mystery involves the unexplained vanishing of two Dutch women, Kris Kremers and Lisanne Froon, in April 2014. They were last seen embarking on a hike along the Pianista Trail near Boquete, Panama. Despite an extensive search effort, including local authorities and aerial support, the women were not found. Ten weeks later, a local woman discovered their backpack containing personal items and a camera with eerie photos. Subsequent searches uncovered scattered remains, raising questions about their fate. The case remains shrouded in mystery, with theories ranging from accidental death to foul play, but no definitive conclusions have been reached.