Recorded on the final day of ACC.26, this video features an unscripted conversation between Dr. Ami Bhatt, Chief Innovation Officer at the American College of Cardiology, and Dr. Harlan Krumholz, Editor-in-Chief of JACC. They reflect on the rapid expansion of artificial intelligence in cardiology, discussing its impact on clinical workflows, research, education, guideline development, and patient empowerment. The discussion explores ethical considerations, trust, human–AI interaction, and the need for clinicians to actively shape AI's role in healthcare. The video highlights both the opportunities and challenges AI presents, emphasizing collaboration, transparency, and clinician leadership as cardiology enters a transformative era.