Sometimes cancer announces itself in unexpected ways—through weakness, electrolyte abnormalities, rashes, or blood clots rather than a visible tumor. In this episode of One Stem at a Time, we break down the high-yield paraneoplastic syndromes you need to recognize on exams, from Lambert-Eaton and myasthenia gravis to SIADH, ectopic ACTH, dermatomyositis, Trousseau syndrome, and hypercalcemia of malignancy. We focus on classic presentations, key cancer associations, underlying mechanisms, and board-ready pearls to help you spot the diagnosis fast when the symptoms don’t seem to fit.