Set primarily in the Harlem neighborhood of New York City in the 1920s, the story centers on the reunion of two childhood friends—Clare Kendry and Irene Redfield—and their increasing fascination with each other's lives. The title refers to the practice of "racial passing" and is a key element of the novel. Clare Kendry's attempt to pass as white for her husband, John (Jack) Bellew, is a significant depiction in the novel and a catalyst for the tragic events.