Patient Case: Sickle Cell Disease, HFrEF, DM2, and More

On this episode, we go over a pharmacotherapy plan for a patient with sickle cell disease, HFrEF, DM2, dyslipidemia, hypertension, POAG, dry eye disease, constipation, GERD, and OSA. Episode 227 Patient Case Information 57-year-old male with sickle cell disease, HFrEF, DM2, dyslipidemia, hypertension, POAG, dry eye disease, constipation, GERD, and OSA comes to your clinic to establish care. His primary concern is the number of sickle cell crisis he has been experiencing (3 ER visits in the last 5 months). He is having significant constipation daily due to his maintenance opioid regimen.  He also reports difficulty controlling his blood glucose. He has experienced 6 hypoglycemic events (BG range between 65 and as low as 42) and is confused as to what he is doing wrong with managing his diabetes. He is also concerned because he is having vivid nightmares almost every night. He also asks about the best artificial tears to get OTC because his Refresh Optive (carboxymethylcellulose) doesn’t seem to be working anymore. Medication List: Losartan 100 mg daily, atenolol 50 mg daily, torsemide 20mg – 4 tabs daily, metolazone 2.5 mg 2 times per week, amlodipine 5 mg daily, simvastatin 40 mg daily, fenofibrate 160 mg daily, lantus 40 units twice daily, humalog 5 units with meals if his pre-meal BG is > 150 mg/dL, metformin ER 500 mg twice daily, hydroxyurea 500 mg – two capsules daily (admits to limited adherence), latanoprost 0.005% nightly, esomeprazole 40 mg twice daily, famotidine 40 mg daily, MiraLax 17 grams daily, and bisacodyl 5 mg daily He has a CPAP at home but admits to using it very infrequently. BMP BP – 165/89 HR – 82 Na – 137 K – 3.6 Cl – 102 CO2 – 26 Glucose – 253 eGFR – 95 mL/min Ca – 8.9 Mg – 1.9 Lipid Profile Chol – 162 LDL-C – 99 HDL-C – 49 Triglycerides  - 242 Echo with EF – 32% B-Type Natriuretic Peptide – 56.2 Vitamin B12 – 367 Hemoglobin – 7.2 Hematocrit – 20.8 MCV – 98.6 Ferritin – 1491.6 (received blood transfusion 2 weeks ago) Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. You can find our account at the website below:  www.patreon.com/corconsultrx If you have any questions for Cole or me, reach out to us on any of the following: Text - 415-943-6116 Mike - [email protected] Cole - [email protected] Instagram and other social media platforms - @corconsultrx