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Pediatric AKI Part 3: Fluid Overload, Dialysis, and CKD Risk
Once acute kidney injury is recognized, early management can significantly influence both short- and long-term outcomes. In this episode, we discuss the principles of pediatric AKI management, including fluid resuscitation, hyperkalemia, metabolic acidosis, fluid overload, indications for renal replacement therapy, and the unique considerations when choosing a dialysis modality in children.
We also review the growing evidence linking pediatric AKI to chronic kidney disease and why long-term follow-up is essential—even after kidney function appears to recover.
Selected References:
KDIGO Clinical Practice Guideline for Acute Kidney Injury (2012).
Ostermann M, et al. Acute Kidney Injury. The Lancet. 2025.
Selewski DT, et al. The AWARE Study: Fluid Overload and Outcomes in Critically Ill Children. Critical Care Medicine. 2023.
Gaudry S, et al. Extracorporeal Kidney-Replacement Therapy for Acute Kidney Injury. New England Journal of Medicine. 2022.
Meena J, et al. Late Outcomes Following Acute Kidney Injury in Children. JAMA Pediatrics. 2026.
Have feedback, corrections, or suggestions for future episodes? We'd love to hear from you at [email protected].
Disclaimer: Kidney Kids is an educational podcast for medical students, pediatric residents, pediatric nephrology fellows, advanced practice providers, and practicing clinicians. The conversations use AI-generated voices portraying fictional physicians. This content is intended for educational purposes only and should not replace clinical judgment, institutional protocols, or consultation with qualified healthcare professionals.
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By Kidney KidsOnce acute kidney injury is recognized, early management can significantly influence both short- and long-term outcomes. In this episode, we discuss the principles of pediatric AKI management, including fluid resuscitation, hyperkalemia, metabolic acidosis, fluid overload, indications for renal replacement therapy, and the unique considerations when choosing a dialysis modality in children.
We also review the growing evidence linking pediatric AKI to chronic kidney disease and why long-term follow-up is essential—even after kidney function appears to recover.
Selected References:
KDIGO Clinical Practice Guideline for Acute Kidney Injury (2012).
Ostermann M, et al. Acute Kidney Injury. The Lancet. 2025.
Selewski DT, et al. The AWARE Study: Fluid Overload and Outcomes in Critically Ill Children. Critical Care Medicine. 2023.
Gaudry S, et al. Extracorporeal Kidney-Replacement Therapy for Acute Kidney Injury. New England Journal of Medicine. 2022.
Meena J, et al. Late Outcomes Following Acute Kidney Injury in Children. JAMA Pediatrics. 2026.
Have feedback, corrections, or suggestions for future episodes? We'd love to hear from you at [email protected].
Disclaimer: Kidney Kids is an educational podcast for medical students, pediatric residents, pediatric nephrology fellows, advanced practice providers, and practicing clinicians. The conversations use AI-generated voices portraying fictional physicians. This content is intended for educational purposes only and should not replace clinical judgment, institutional protocols, or consultation with qualified healthcare professionals.