AACAP President, Gabrielle A. Carlson, MD speaks with Dr. Ellen Leibenluft, Senior Investigator and Chief of the Section on Mood Dysregulation and Neuroscience Intramural Research Program at the National Institute of Mental Health, about how to answer the questions of irritability or early onset bipolar, how early can bipolar disorder be diagnosed, and where do outbursts fit in the study of irritability.