For years, we have performed pediatric heart transplants following the declaration of brain death in donors. To this point, those who die of cardiovascular complications have not been considered for heart donorship. How are advances in this area forcing us to reconsider the prospect of a heart transplant after cardiocirculatory death? Host Dr. Mark Nolan Hill considers the potential ramifications of this fascinating investigation with Dr. Mark Boucek, director of pediatric cardiovascular services at Joe DiMaggio Children's Hospital in Hollywood, Florida, and the lead author of research published in the New England Journal of Medicine on three cases of pediatric heart transplantation after cardiocirculatory death. Does this successful restarting of the heart in transplant recipients suggest that the donor's heart stoppage was not irreversible?