This episode delves into the utility of the 5-SENSE score in localizing seizure onset zones in pediatric patients undergoing stereoelectroencephalography (SEEG). We review the study "Performance of the 5‐SENSE score in a pediatric and young adult cohort of 100 consecutive stereoelectroencephalography cases," published in Epilepsia in 2026, examining its full text. The research involved a retrospective analysis of 100 pediatric and young adult patients undergoing SEEG, evaluating the score's performance in accurately predicting seizure onset. Key findings highlight the score's effectiveness and its potential impact on surgical planning and patient outcomes. This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional for any health concerns.