On this episode, Pip and Rich discuss Jaber et al. Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism: Primary Results of the PEERLESS Randomized Controlled Trial. PEERLESS was a trial that enrolled patients with intermediate-risk (sub-massive) PE and randomised them to either large-bore mechanical thrombectomy or catheter directed thrombolysis. The headline finding from PEERLESS is that mechanical thrombectomy is superior to catheter directed thrombolysis but as ever, if you read beyond the abstract, you will find that it is much more complex than that. The study used an interesting primary endpoint called "win ratio" and the show includes a detailed explanation and analysis of what this is, its benefits, and its drawbacks.

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