The clinical presentation and epidemiology of infective endocarditis (IE) have evolved over time. While the cornerstones of IE treatment remain antimicrobial therapy and surgery, percutaneous mechanical aspiration (PMA) has emerged as an option for carefully selected patients as a complementary modality, based on retrospective data, case series, and expert experience. In this comprehensive review, published in JSCAI, the authors summarize the proceedings from an inaugural summit dedicated to the discussion of PMA in the global management of IE, consisting of experts across multiple disciplines from diverse geographic regions and care environments. This video conversation highlights the comprehensive review with a panel discussion featuring Cindy Grines, MD, MSCAI, Lucas Marinacci, MD, Kenneth Rosenfield, MD, MSc, MSCAI, & Molly Paras, MD.Read the article: https://doi.org/10.1016/j.jscai.2024.102283