Today we interview Steven de Soir, postdoctoral researcher at uvain Drug Research Institute (UCLouvain) & LabMCT of the Queen Astrid Military Hospital.

We cover his work with phages and antibiotics against Pseudomonas aeruginosa biofilms, which was covered in his article Exploiting phage-antibiotic synergies to disrupt Pseudomonas aeruginosa PAO1 biofilms in the context of orthopedic infections (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10783084/) .

Some things you can hear:

What is Steven’s research focus?

Why do we need phages in orthopedic infections?

How do you find a balance between phages and antibiotics in a patient?

Why did you choose certain specific antibiotics?

Did you find synergies between phage and antibiotics?

What about your phage cocktails?

Combined treatment or sequential treatment?

What is the biofilm respiratory rate?

This and much more on the science and some personal opinions and advice in the episode!