various antilipidemic medications used to manage high cholesterol and reduce cardiovascular risks. It details several drug classes, including bile acid sequestrants, nicotinic acid, ACL inhibitors like bempedoic acid, and advanced siRNA therapies such as inclisiran. Each section highlights specific therapeutic indications, potential drug interactions, and essential nursing considerations for patient safety. The source emphasizes the importance of monitoring for adverse effects like liver dysfunction, muscle pain, and vitamin deficiencies. Additionally, it underscores the necessity of combining pharmacological treatments with a cholesterol-lowering diet and thorough patient education. Final summaries provide key clinical takeaways for healthcare providers regarding statin-intolerant clients and long-term monitoring protocols.