Discussed on 5 drugs : 1. Difference between reversibile anti cholinesterase inhibitors and irreversible anti cholinesterase inhibitors ; ANTIDOTE : pralidoxine (2 PAM - 2 purified Aldoxime methyl chloride ) , 2. METHACHOLINE : bronchial hyperactivity , more potent for M2 receptor , but in this test we used because of M3 , 3. OPIOD SIDE EFFECT : Constipation 4. BRADYCARDIA (DOC) : ATROPINE 0.5 to 1 mg 5. METFORMIN: malabsorption of B12