WARFARIN. Introduction , mechanism of action , Side Effects :- BLEEDING , RETROPERITONEAL HEMORRHAGE ,PURPLE TOE SYNDROME , OSETEOPOROSIS RELATED BONE FRACTURE .. CLINICAL CONSIDERATIONS:- FIRST TRIMESTER - FETAL WARFARIN STNDROME - Nasal hypoplasia , narrowed Nasal bridge , other limbic and cardio abornmalities , SECOND & THIRD TRIMESTER : CNS abornmalities , ocular defects , seizures , low birth weight. ... ANTIDOTE : PHYTOMENADIONE (VIT k) CYP P450 INHIBITORS: macrolides, Flucanazole , Protease inhibitors. CYP 450 INDUCERS : Phenytoin , Carbamazepine, Rifampin .. insta id : Srinath Kalepu .. LINKEDIN : Kalepu Srinath