The PODCAST outlines significant updates to the Pharmacy First Clinical Pathways, scheduled to take effect on October 1, 2025. These revisions introduce several key changes across various pathways, including more emphasis on red flag consideration and the addition of gateway points for urgent escalation to A&E or calling 999. Specific pathways, such as those related to UTIs and shingles, feature clarified definitions and new red flags for onward referral, while women with diabetes are now explicitly excluded from certain services. Furthermore, there are important procedural updates, such as the requirement for examinations to occur in a consultation room, and new guidance regarding claimable points for self-care advice and suspected conditions.