ASHP and ASHP Foundation Pharmacy Forecast 2025, a comprehensive report offering strategic planning guidance for pharmacy departments in hospitals and health systems. It examines critical issues impacting the pharmacy profession and healthcare landscape over the next five years, including the business of healthcare, managing ultra-high-cost drugs, addressing the primary care gap, implementing whole person health, navigating generative artificial intelligence, and stabilizing the pharmacy workforce. Based on a survey of pharmacy leaders, the forecast provides insights and recommendations to help organizations proactively address emerging trends and prepare for future challenges in patient care and medication management.