Chandrababu Naidu played a pivotal role in the establishment of the Indian School of Business (ISB) in Hyderabad. In 1999, during his tenure as the Chief Minister of undivided Andhra Pradesh, Naidu worked closely with business leaders and academic experts to bring the ISB to Hyderabad. His vision was to create a world-class business school that would contribute to the growth of the business and management education sector in India.

Naidu provided support in terms of land allocation and infrastructure, helping to set up the ISB campus in Hyderabad. The school, inaugurated in 2001, has since become one of the leading business schools in the country. Chandrababu Naidu's proactive efforts and commitment to promoting education and industry in the region played a significant role in the establishment and success of the Indian School of Business in Hyderabad.