Plasma-lyte vs. Saline (0.9% NaCl) in the Critical Ill: Reviewing the PLUS Trial

The PLUS Trial compared plasma-lyte to 0.9% NaCl (aka normal saline) in patients who were critically ill and needed IV fluids. In this episode, we review the PLUS trial that compared Plasma-lyte to Saline (0.9% NaCl) in critically ill patients. We discuss the rationale behind the trial, its design, and the key findings. We also delve into the implications of the study results and explore how this evidence could impact clinical practice. Additionally, we touch on the broader debate surrounding the use of crystalloid solutions in critical care and discuss the limitations of the study. Whether you are a clinician or a student, this episode will provide you with a deeper understanding of the current evidence-based practices regarding the use of fluids in critically ill patients.

Show Notes: https://eddyjoemd.com/plus-trial/

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Citation: Finfer S, Micallef S, Hammond N, Navarra L, Bellomo R, Billot L, Delaney A, Gallagher M, Gattas D, Li Q, Mackle D, Mysore J, Saxena M, Taylor C, Young P, Myburgh J; PLUS Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. N Engl J Med. 2022 Jan 18. doi: 10.1056/NEJMoa2114464. Epub ahead of print. PMID: 35041780.

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