The Prince Mahidol Award Conference (PMAC) is an annual event held in Bangkok, at which humanitarian leaders and experts in various disciplines meet to discuss global challenges, including health crises and climate change. This year, the conference ran from the 25th to the 29th of January, featuring seven sessions with international speakers. The theme of PMAC 2022 was ‘The World We Want: Actions Towards a Sustainable, Fairer and Healthier Society’. This article highlights some of the main global issues and megatrends discussed at the conference.