This episode of the NIH Collaboratory Grand Rounds podcast follows the conversation on Electronic Health Records (EHRs) between Dr. Lesley Curtis and Dr. Joshua C. Denny, Chief Executive Officer of the All of Us Research Program. The discussion covers questions on Dr. Denny’s early experience with EHRs, his journey on working with All of US and EHRs, and how the program is addressing the impact of the COVID-19 pandemic. This discussion follows Dr. Jacqueline Corrigan-Curay and Dr. Denny’s keynote presentation of a Grand Rounds Series titled Advances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials.