POEM of the Week Podcast by Mark Ebell and Michael Wilkes

What's POEM of the Week Podcast about?

Each week, Dr. Mark Ebell, POEMs Editor, joins Dr. Michael Wilkes, NPR correspondent and Vice-Dean of the UC-Davis Medical School, for a five minute discussion about an important recent medical study reviewed by the POEMs editors. POEMs provide synopsised reviews of studies that could affect a clinician's practice, and the discussion in this podcast provides additional depth and insight into the issue covered by the POEMs synopsis. More about POEMs and it's companion point-of-care search tool, Essential Evidence Plus, at www.essentialevidenceplus.com.

What's POEM of the Week Podcast about?

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POEM of the Week Podcast episodes:

Episode 695: Monoclonal antibodies for Alzheimer disease: A lack of clinically meaningful benefits, plus significant harms

Episode 694: Patient reminders combined with clinician audit and feedback increases human papillomavirus vaccine uptake

Episode 693: Canadian Thoracic Society guidelines for pharmacotherapy of stable chronic obstructive pulmonary disease

Episode 692: Scottish screening: 0 cases of invasive cervical cancer in women who received at least 1 dose of bivalent HPV vaccine at 12 or 13 years of age

Episode 691: High-dose recombinant flu vaccine: NNT = 3000 to prevent one more infection, no impact on hospitalization

Episode 690: Delivery of bad news via phone = in-person delivery

Episode 689: PCI is better than placebo for stable angina in patients who do not take anti-anginal medications (ORBITA-2)

Episode 688: Wait-and-watch is an option for patients with symptomatic but uncomplicated gallstones

Episode 687: Brexpiprazole improves agitation scores in adults with Alzheimer disease who have agitated behaviors

Episode 683: Cognitive behavioral therapy effective for patients with fatigue associated with long COVID

Episode 686: ACC/AHA guideline for the management of patients with chronic coronary disease

Episode 685: Positive, rather than negative, messaging of weight loss might motivate patients to try to lose weight

Episode 680: Wrong blood pressure cuff size can falsely increase or decrease readings

Episode 679: Early BP treatment for acute ischemic stroke has no impact on mortality or functional outcomes (CATIS-2)

Episode 682: The risk of breast cancer overdiagnosis is high for older women

Episode 681: Esketamine is superior to quetiapine for remission of treatment-resistant depression (ESCAPE-TRD)

Episode 678: Acetaminophen and ketorolac are more effective than morphine in alleviating pain in adults with renal colic

Episode 677: Terbinafine 250 mg once daily — 12 weeks on, 12 weeks off, 4 weeks on — is preferred for onychomycosis in adults

Episode 676: Nearly zero risk of sexually transmitting HIV when viral loads are less than 1000 copies per mL

Episode 675: Overweight/obese adults with symptomatic COVID-19 treated with metformin are less likely to develop long COVID (COVID-OUT)

Episode 674: Amoxicillin is no more likely to cause rash than any other antibiotic in patients with mononucleosis

Episode 673: Once-and-done screening colonoscopy has higher rates of adherence than yearly fecal-based blood testing

Episode 672: Early treatment of gestational diabetes is modestly beneficial for neonatal and maternal outcomes

Episode 671: Most people tolerate bedtime thiazide diuretics

Episode 670: Cholesterol-reducer evolocumab associated with a nonsignificant increase in cardiovascular mortality (FOURIER)

Episode 669: Mifepristone effective and safe for the treatment of adenomyosis with pain symptoms

Episode 668: Direct oral anticoagulants are noninferior to low-molecular-weight heparin to prevent recurrent VTE in adults with cancer

Episode 667: Early return to activity improves symptoms in children with concussion

Episode 666: Tailored exercise program improves function and reduces pain due to knee osteoarthritis

Episode 665: A daily multivitamin has modest impact on memory in older adults (COSMOS-WEB)

Episode 664: Older treatments for type 2 diabetes do not affect patient-oriented outcomes

Episode 663: Intravenous hydrocortisone reduces all-cause mortality in severe community-acquired pneumonia (CAPE COD)

Episode 662: Postexposure prophylaxis with doxycycline in men who have sex with men and transgender women with or at risk of HIV reduces STI risk (NNT = 5)

Episode 661: Bivalent respiratory syncytial virus (RSV) vaccine given to mothers reduces total and severe RSV infections in infants

Episode 660: Bempedoic acid 180 mg reduces risk of nonfatal myocardial infarction and revascularization; NNT = 42 in primary prevention group (CLEAR)

Episode 659: Discectomy for sciatica provides short-term relief for leg pain

Episode 658: Active surveillance reduces the need for surgery, with no change in mortality, at the price of a small increase of metastatic disease (ProtecT)

Episode 657: Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND)

Episode 656: Among antidepressants, only serotonin-norepinephrine reuptake inhibitors are effective for pain

Episode 655: Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9)

Episode 654: Brief behavioral therapy improves sleep in older adults with chronic insomnia

Episode 653: Brief behavioral therapy improves sleep in older adults with chronic insomnia

Episode 652: Mindfulness-based stress reduction is noninferior to escitalopram for adults with anxiety disorder

Episode 651: No benefit with torsemide over furosemide for posthospitalization treatment of heart failure (TRANSFORM-HF)

Episode 650: Lecanemab does not significantly improve cognition in early Alzheimer's disease, is expensive, and causes brain edema and hemorrhage in some patients

Episode 684: Network meta-analysis: Limited data show that high-dose aspirin decreases incidence of colorectal cancer

Episode 649: Chlorthalidone no better than hydrochlorothiazide for hypertension

Episode 648: Twice-daily low-dose aspirin is similar to enoxaparin for thromboprophylaxis after inpatient treatment for fracture (PREVENT CLOT)

Episode 647: Tell patients their new knee won't wear out sooner with hard use

Episode 646: Majority of CIN2 regress in women aged 25 to 30 years