Insights:

Increased susceptibility to encapsulated bacterial sepsis (side note, in Bruton agam, also increased risk of this)

Child greater than adults (fewer memory B cells)

Immune reasons: fewer antibody responses to blood bourne pathogens, fewer phagocytes (side note, in Bruton agam, also increased risk of this)

Need for vaccines against encapsulated bacteria (pneumovax, HiB, MenACWY, MenB)

References

Abbas, A., Lichtman, A., Pillai, S., Baker, D. and Baker, A. (n.d.). Cellular and molecular immunology. 9th ed.

Kumar, V. (2017). Robbins basic pathology international edition. S.l. Elsevier - Health Science.