Practical Significance focuses on the passion and commitment members bring to advancing the ASA’s mission of promoting the practice and profession of statistics. Cohosts Donna LaLonde and Ron Wasserstein chat with two guests—Susan Paddock, executive vice president and chief scientist at NORC at the University of Chicago, and Bo Li, professor at Washington University in St. Louis—about the career-changing and life-enhancing impact of their service to the American Statistical Association community.