In this forward-looking episode of Practical Significance, co-hosts Donna LaLonde and Ron Wasserstein sit down with a powerhouse panel to explore where statistics is headed over the next decade. Kathy Ensor (Rice University), Lance Waller (Emory University), and Brittany Segundo (National Academies) dive into a major National Academies consensus study: Frontiers of Statistics in Science and Engineering: 2035 and Beyond.