What happens when you combine statistical expertise, cross-cultural collaboration, and a mission to build statistical capacity internationally? You get the ASA’s Educational Ambassador Program—and one inspiring episode of Practical Significance! Cohosts Donna LaLonde and Ron Wasserstein sit down for a lively conversation with three dynamic guests: Carolina Franco (NORC at The University of Chicago); Andrzej Kosinski (Duke University School of Medicine); and Paulo Canas Rodrigues (Federal University of Bahia).