COR2ED - Oncology Medical Conversation Video

Pre-analytical phase challenges and biomarker testing in HER2+ metastatic breast cancer

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Pre-analytical Phase Challenges and Biomarker Testing in HER2+ Metastatic Breast Cancer 

 

Key clinical takeaways:  

  • Metastatic breast cancer (mBC) is a complex, heterogeneous disease requiring multidisciplinary collaboration. Pathologists are central to this process to ensure accurate interpretation and optimal patient management   
    • Incorporating HER2-low and HER2-ultralow categories in biomarker testing is critical for mBC due to the demonstrated efficacy of HER2-targeted antibody-drug conjugates, such as trastuzumab deruxtecan, in these patient subsets, expanding therapeutic options beyond traditional HER2-positive cases   
      • High-quality pre-analytical handling and nuanced interpretation are essential for accurate HER2 classification, particularly for HER2-low and –ultralow disease. Small errors in testing or interpretation can lead to missed treatment opportunities. 

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        This is the full video. Watch the shorter highlights video here: https://cor2ed.com/precision-oncology-connect/programmes/biomarker-testing-breast-cancer/?media=0 

         

        Listen to the audio version of this conversation on Spotify, Apple, or on the COR2ED website, where you can also download the accompanying one-page snapshot: https://cor2ed.com/precision-oncology-connect/programmes/biomarker-testing-breast-cancer/?media=2 

          

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        This content is intended for healthcare professionals only.  

        This video is supported by an Independent Education Grant from Daiichi Sankyo. 

         

        This video is developed by cor2ed.com 

        Published on March 2026. 

         

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        COR2ED - Oncology Medical Conversation VideoBy COR2ED Medical Education