This mini-review investigates the potential of precision medicine and personalized nutrition in managing health challenges in perimenopausal women, particularly focusing on the role of genetic polymorphisms in metabolic pathways. The key genetic polymorphisms in the COMT, FUT2, and MTHFR genes are examined - these polymorphisms influence neurotransmitter metabolism, gut microbiota composition, and folate homeostasis respectively. These genetic variations play a critical role in modulating hormonal fluctuations, metabolic imbalances, and nutrient absorption during perimenopause. The review emphasizes the impact of specific genetic variations on stress response, mood disorders, vitamin B12 absorption, cortisol metabolism, homocysteine levels, and cardiovascular risk. The review also discusses the integration of machine learning in precision medicine to optimize personalized interventions using genetic data. This approach allows for tailored nutritional and therapeutic strategies to mitigate the metabolic and psychological effects of perimenopause. The authors suggest that genetic testing should be incorporated into preventive care for perimenopausal women to enhance quality of life and promote healthy aging.

Content curated by: Dr. Cameron Jones, PhDPublic Health Expert, Fungal Biologist, and Science CommunicatorCEO of Biological Health Services, a consultancy and lab specializing in indoor air quality.Adjunct Faculty at the National Institute of Integrative Medicine, Australia.Founder, BioMedix & House of Pot, BangkokFor more insights on public health and cutting-edge research, visit drcameronjones.com and drcameronjones.tvThis podcast is part of an innovative science communication initiative powered by Google's Notebook LM, an AI-driven tool that helps bring complex research to life by creating dynamic conversations and easily digestible summaries. Stay tuned for more engaging discussions at the intersection of science, health, and wellness.

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