What do patients really want to know about PrEP? How can healthcare providers answer those questions with clarity, confidence, and compassion? In this episode of PrEP Essentials, infectious disease specialist Jonathan Shuter, and Kendall Lawson and Arianna Martinez from AIDS Alabama have a practical discussion about the concerns patients bring into the exam room. Together, they explore the questions patients are often hesitant to ask, including side effects, missed doses, insurance coverage, stigma, adherence, and long-term safety, while offering real-world strategies for building trust, improving communication, and making HIV prevention conversations more effective and approachable.