Dr. Drew Wilson, ID Pharmacy Resident, discusses the new options for pre-exposure prophylaxis (PrEP) to prevent HIV infection. Options discussed include oral PrEP (Truvada, Descovy), cabotegravir, and a newer option, lenacapravir. A prescribing algorithm is also presented, and the topic of developing resistance is also covered. Lastly, Dr. Wilson touches upon other novel agents for PrEP, as well as DoxyPEP for the prevention of bacterial STIs.