In this first episode, Center Faculty Director, Dr. Holly Raffle, interviews Ohio Mental Health and Addiction Services (OhioMHAS) Director Lori Criss. Their conversation explores the state’s role in behavioral health promotion; highlights the strong relationship between the state, the Ohio Center of Excellence for Behavioral Health Prevention and Promotion, and community prevention partners; and maps out a way forward for prevention science in Ohio. An Ohio native, Director Criss’ insight into the historical roots of Ohio’s role in prevention leadership frames the discussion.