Most Australians know alcohol isn't great for them — but almost nobody knows it directly causes 7 types of cancer, or that just 3 standard drinks a week raises breast cancer risk by 15%. Dr Chris Davis is a GP and addiction specialist who built a telehealth program to make alcohol treatment actually accessible — no waiting lists, no rehab wards, no judgment. In this episode we get into the chemistry of what alcohol actually does to your body, why your sleep is being quietly destroyed, and what the data says about who's really drinking at risky levels in this country. If you drink — or love someone who does — this one's worth your time.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice.

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See omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice.

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Lucas Aoun is a naturopath and men's health researcher with a Bachelor of Health Science whose work on natural testosterone optimisation gained the attention of Andrew Huberman. In this episode, he walks through the full hormone production pathway from the hypothalamus to the testes, explains which blood markers most GPs overlook, and outlines the lifestyle, nutrition, and supplementation strategies he has used to bring his own testosterone to near-1,000 nanograms per deciliter naturally. The conversation also covers structural causes of low testosterone, the role of HBOT and sleep in hormone health, and when TRT becomes the appropriate next step.

Check out Lucas's stack here: https://www.inb4supps.com/products/peak-t

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Most people think longevity is about diet and supplements. Alexis Fernandez, cognitive neuroscientist, says the real killers are chronic stress, isolation, and outsourcing your brain to your phone. In this episode of Project 100, Mark Bouris sits down with Alexis to unpack what the science on centenarians actually shows — and it's simpler, and more confronting, than most people want to hear. From cortisol dysregulation to synaptic pruning to why resistance training is the best thing you can do for your brain, this conversation will change how you think about what it means to age well.

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Most people taking supplements are wasting their money — not because supplements don't work, but because what they're swallowing never actually reaches the cells that need it. Bioavailability scientist George Kokkinis has spent 30 years at the intersection of chemistry, regulation, and human performance, and what he shares in this episode will change how you read every supplement label. From vitamin D3 and NMN to berberine, CoQ10, and omega-3s, we break down what's actually getting absorbed, what's heading straight to the toilet, and what to look for before you spend another dollar. This is the supplement conversation nobody in the industry wants you to have.

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In this episode of Project 100, I sit down with one of Australia's leading cardiothoracic surgeons to understand what's actually happening inside your heart, what your cholesterol numbers really mean, and why the gap between men and women in heart disease outcomes is more serious than most people realise. This is the conversation that will change how you think about what you're doing to your body right now — not in 30 years' time.

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Dr Stacy Sims is one of the world's leading exercise physiologists and nutrition scientists specialising in women's health, and she joins Project 100 to explain why the science women have been given is largely based on male data — and what that means for how women should actually train, eat, and protect their healthspan.

From the cellular differences between the sexes, to perimenopause, creatine, protein timing, Alzheimer's risk, and why sleep beats everything else — this is a conversation every woman (and the people who love them) needs to hear.

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Sebastian Oreb, better known as the Australian Strength Coach, has trained some of the world’s strongest athletes, including Hafþór Björnsson, Alex Simon, and elite professional athletes across multiple sports. 

In this episode of Project 100, Sebastian breaks down the science of building muscle, explaining progressive overload, the best rep ranges for muscle growth, and why strength is one of the biggest predictors of healthy ageing.

We also cover:

• Progressive overload explained simply
• Compound vs isolation exercises
• The best rep ranges for building muscle
• How often you should train
• Strength vs hypertrophy
• Why muscle matters for longevity
• Common gym mistakes that limit results
• How to build muscle safely at any age

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Tim Piatowski is one of Australia's leading researchers on peptides and enhancement drugs, running the world's first steroid-checking trial and service.

In this conversation, we cover everything from what peptides actually are to the underground markets driving their use across Australia. Tim explains the science behind popular compounds like BPC-157 and GHK-Cu, the risks of unregulated products, and why Australia's regulatory approach is pushing people toward dangerous illicit markets. We also explore the potential for peptides in healthy ageing, injury recovery, and why our government's silence on this growing trend is creating more problems than solutions.

We speak about:

• What peptides are and how they work as signalling molecules
• BPC-157 for tissue healing and inflammation reduction
• GHK-Cu copper peptides for collagen synthesis and skin health
• Growth hormone releasing peptides like CJC-1295 and tesamorelin
• The contamination crisis in illicit enhancement drugs
• Legal pathways vs underground markets in Australia
• How peptides could transform healthy ageing and falls prevention

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Maria Andriano is one of Australia's leading strength coaches whose incredible physique at 54 proves that muscle truly is the fountain of youth. 

In this episode, she reveals why building and maintaining muscle mass isn't just about aesthetics—it's your first line of defence against aging, illness, and frailty.

• Why women lose 10% muscle mass every decade after 30 and how to stop it
• The five compound movements every woman should master for longevity
• Post-workout nutrition timing that actually builds muscle (not just burns calories)
• How strength training during menopause can reverse hormonal decline
• Why the Ozempic generation is setting themselves up for metabolic disaster
• Maria's exact training split for maximum muscle gain with minimal gym time
• The truth about why most people plateau after years of training

All content is for informational purposes only and is not medical advice.

See omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice.

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Professor Matthew Kiernan is CEO of Neura and one of the nation's leading neurologists tackling the growing dementia crisis.

Kiernan explores why dementia is now Australia's number one cause of death, the modifiable risk factors that could prevent 45% of cases, and the groundbreaking monoclonal antibody treatments now available for Alzheimer's disease.

Kiernan explains how the Western Pacific region carries 60% of the world's dementia burden and why researchers are racing to develop blood biomarkers that could detect brain diseases decades before symptoms appear. We also get into:
• Why dementia has overtaken heart disease as Australia's leading killer
• The role of vascular health in brain function and cognitive decline
• Blood biomarkers coming within five years for early detection
• Monoclonal antibody treatments for Alzheimer's now available in Australia
• The connection between contact sports, head injuries and neurodegeneration
• How GLP-1 medications are showing promise for brain health
• Sleep's critical role in clearing toxic proteins from the brain

Join my exclusive Mentored+ community: https://mentored.com.au/become-a-member/
Subscribe to the Mentored newsletter here: https://mentored.com.au/newsletter

See omnystudio.com/listener for privacy information.