A detailed overview of advanced magnetic resonance imaging (MRI) techniques for studying cardiovascular physiology and disease. The text covers the vast capabilities of cardiac MRI, which range from molecular-scale imaging using hyperpolarized MRI and in vivo spectroscopy to macroscale dynamic imaging of structure and function. Several methodologies are explored, including diffusion MRI to illuminate cardiac tissue architecture, Magnetic Resonance Elastography (MRE) for non-invasive stiffness estimation, and the use of multinuclear imaging for assessing cellular metabolism and ion concentrations. Furthermore, the material discusses technical challenges and solutions in cardiac MRI, such as motion compensation for free-breathing acquisitions and the use of compressed sensing to accelerate image acquisition for both preclinical and clinical applications, including the assessment of atherosclerotic plaque and myocardial viability in ischemic heart disease.
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