CPT: Pharmacometrics & Systems Pharmacology’s (PSP) 2025 themed issue focused on Pediatric Rare Diseases, which impact more than 25 million people worldwide. Listen as PSP Associate Editors Ping Zhao and Rajat Desikan and Guest Editor Jane Knöchel discuss the conception and planning of this exciting issue as well as articles and topics they found especially interesting and insightful. Interested in publishing with ASCPT? You can find our open Calls for Papers here.