Anger triggers a physiological response known as the "fight-or-flight" response, involving the release of stress hormones like adrenaline and cortisol. If anger persists, the body remains in a heightened state of arousal, leading to increased heart rate, elevated blood pressure, and a constant release of stress hormones. This prolonged physiological activation can negatively impact various bodily systems, contributing to health problems such as cardiovascular issues, compromised immune function, and chronic inflammation.

The practice of forgiveness with compassion has been linked to improved mental and physical health outcomes. It reduces stress, anxiety, and depression, leading to enhanced overall well-being and a healthier lifestyle.